Solid phase synthesis and opioid receptor binding activities of (D-Ala2,D-Leu5)enkephalin analogs containing a fluorinated aromatic amino acid.
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (11) , 3162-3163
- https://doi.org/10.1248/cpb.38.3162
Abstract
Five [D-Ala2, D-Leu55]enkephalin (DADLE) analogs containing fluorinated Tyr1 or Phe4 residue, that is, [Phe(2F)4](I), [Phe(3F)4] (II), [Tyr(3F)1] (IV) and [Try(2F)1] (V), were synthesized by the solid phase method and their opioid receptor affinities were examined. Affinity profiles of five derivatives for the .mu.- and .delta.-receptor were similar to those of DADLE, and the affinity for .kappa.-receptor was zero or negligible.This publication has 3 references indexed in Scilit:
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