[18F]FDG-PET Reveals Temporal Hypometabolism in Patients With Temporal Lobe Epilepsy Even When Quantitative MRI and Histopathological Analysis Show Only Mild Hippocampal Damage

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Abstract
POSITRON emission tomography (PET) with fludeoxyglucose F 18 ([18F]FDG) has shown the region of reduced interictal glucose metabolism in the epileptogenic temporal lobe,1-4 and high-resolution quantitative magnetic resonance imaging (QMRI)5-7 has reduced hippocampal volume (HCV) and prolonged T2-weighted signal (HCT2) in the epileptic hippocampus in patients with intractable temporal lobe epilepsy (TLE). Histopathologically, hippocampal damage (HD) found in 60% to 70% of patients with TLE contains neuronal loss in the hilus and CA1 subfield, gliosis, and synaptic reorganization.8-10