A processed human immunoglobulin epsilon gene has moved to chromosome 9.
- 1 October 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (19) , 5956-5960
- https://doi.org/10.1073/pnas.79.19.5956
Abstract
Processed genes.sbd.genes that resemble processed RNA transcripts rather than interrupted genomic sequences.sbd.were identified as dispersed members of several gene families. A processed gene is described that is 1 of the 3 human IgE-like sequences present in the human genome. The processed IgE gene has precisely lost its 3 intervening sequences, thereby fusing its 4 coding domains. The homology of the gene to its functional counterpart ends in an A-rich tail followed by an 11-base-pair sequence that is directly repeated 150 base pairs 5'' to its 1st coding domain. The processed gene is located on human chromosome 9 rather than on chromosome 14, the site of the active Ig locus. The structure and evident mobility of this sequence support the concept that sequences can move about in the genome via RNA intermediates and that processed genes are a prominent feature of genomic structure.This publication has 19 references indexed in Scilit:
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