Selective Postoperative Inhibition of Gastrointestinal Opioid Receptors
Top Cited Papers
Open Access
- 27 September 2001
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 345 (13) , 935-940
- https://doi.org/10.1056/nejmoa010564
Abstract
Postoperative recovery of gastrointestinal function and resumption of oral intake are critical determinants of the length of hospital stay. Although opioids are effective treatments for postoperative pain, they contribute to the delayed recovery of gastrointestinal function.Keywords
This publication has 18 references indexed in Scilit:
- Postoperative ileus: a preventable eventBritish Journal of Surgery, 2000
- Effect of morphine and incision length on bowel function after colectomyDiseases of the Colon & Rectum, 2000
- Oral naloxone reverses opioid-associated constipationPain, 2000
- Prokinetic Agents for the Treatment of Postoperative Ileus in Adults: A Review of the LiteraturePharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1999
- An investigation of the ability of oral naloxone to correct opioid-related constipation in patients with advanced cancerPalliative Medicine, 1996
- Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility DisordersJournal of Medicinal Chemistry, 1994
- Treatment of opioid-induced constipation with oral naloxone: A pilot studyClinical Pharmacology & Therapeutics, 1992
- Morphine effects on human colonic myoelectric activity in the postoperative periodThe American Journal of Surgery, 1992
- Postoperative ileusDigestive Diseases and Sciences, 1990
- PHARMACOKINETICS OF INTRAVENOUS NALOXONE IN HEALTHY VOLUNTEERSAnesthesiology, 1984