Quantitative Relationships between Dynamics and Kinetics of Drugs: A Systems Dynamics Approach
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Drug Metabolism Reviews
- Vol. 15 (1-2) , 365-382
- https://doi.org/10.3109/03602538409015072
Abstract
The body is considered as a system composed of a number of subsystems. The response(s) of a drug is a complicated function of the concentration in the blood plasma, which in turn is some function of the dosage input. The dose-response curve of a drug in a subsystem (e.g., isolated organ) is, over a limited concentration range, a linear function of the logarithm of the concentration. The logarithm of the concentration in the plasma is, again over a limited range, a linear function of time. Time-effect curves in the intact organism may therefore be a linear function of time. In reality, the situation is far more complex, because of nonlinear kinetics, nonlinear kinetics of effects in the subsystems, and adaptation phenomena based on feedback regulation, as is illustrated by examples. It is concluded that one should not only consider the body as a system but also study it as a system; that is, apply the dynamic system approach in pharmacology.Keywords
This publication has 12 references indexed in Scilit:
- Receptor Theories and Quantitative Effect Versus Dose-Concentration RelationshipDrug Metabolism Reviews, 1984
- Climate Impact of Increasing Atmospheric Carbon DioxideScience, 1981
- A linear recirculation model for drug dispositionJournal of Pharmacokinetics and Biopharmaceutics, 1979
- The osmotic minipump: a new tool in the study of steady-state kinetics of drug distribution and metabolismJournal of Pharmacy and Pharmacology, 1978
- Bioavailability and Pharmacokinetic Analysis of Drug Responding SystemsAnnual Review of Pharmacology and Toxicology, 1978
- Atmospheric Carbon Dioxide and Carbon Reservoir ChangesScience, 1978
- Linear and nonlinear kinetics of drug elimination I. Kinetics on the basis of a single capacity-limited pathway of elimination with or without simultaneous supply-limited eliminationJournal of Pharmacokinetics and Biopharmaceutics, 1974
- Circulation: Overall RegulationAnnual Review of Physiology, 1972
- Kinetics of psycho-motor stimulant drug actionEuropean Journal of Pharmacology, 1968
- Kinetic of pharmacalogic activity of succinylcholine in manJournal of Pharmaceutical Sciences, 1967