Analysis of eight cases of neonatal meningitis and sepsis due to Enterobacter sakazakii

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Abstract
Eight cases of neonatal meningitis due to E. sakazakii (formerly known as yellow-pigmented E. cloacae) which occurred in The Netherlands during the last 6 yr were investigated retrospectively. Two patients had necrotizing enterocolitis and meningitis simultaneously. Despite treatment (in most cases with ampicillin and sentamicin), the fatality rate was 75%. Strains were much more susceptible to some of the new .beta.-lactam antibiotics than to ampicillin. A mode of transmissin other than passage through the birth canal was likely, at least for some patients. A cluster of 4 patient strains in 1 hospital had almost identical plasmid DNA profiles. Two strains isolated from formula at the same hospital 2 days after the onset of 1 case had different profiles, as did the strains from patients in other hospitals.