Glutathione conjugation in the detoxication of (Z)-1,3-dichloropropene (a component of the nematocide D-D) in the rat
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 9 (3) , 149-156
- https://doi.org/10.3109/00498257909038715
Abstract
1. (Z)-1,3-Dichloro[2-14C]propene([14C](Z)-DCP) when dosed orally to rats gave 82-84% of the radioactivity in the urine 24 h after treatment. Most of this 14C (92%) was present as N-acetyl-S-((Z)-3-chloroprop-2-enyl)cysteine ((Z)-DCP mercapturic acid). 2. When (Z)-DCP was incubated with glutathione and rat liver cytosol (containing glutathione S-alkyl transferase), very rapid loss of (Z)-DCP was observed. The product of this reaction was S-[(Z)-3-chloroprop-2-enyl)]glutathione.This publication has 4 references indexed in Scilit:
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- Metabolic Demethylation of the Insecticide Dimethyl-vinphos in Rats, in Dogs, and in vitroXenobiotica, 1976
- The Alkylating Properties of OrganophosphatesXenobiotica, 1972
- The excretion and retention of components of the soil fumigant D-D and their metabolites in the ratFood and Cosmetics Toxicology, 1971