Oestrogens and Post-Menopausal Bone Loss

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Abstract
The place of estrogen and progestogen therapy in the prevention of [human] post-menopausal bone loss is evaluated. The benefit-risk ratio of such estrogen or progestogen therapy was examined. Osteoporosis consequent on loss of ovarian activity, pathophysiology of post-menopausal osteoporosis, prevention of post-menopausal bone loss, and the risks of long-term estrogen therapy were discussed. Estrogens have an important part to play in the prevention of post-menopausal osteoporosis. For each individual patient the physician must bear in mind the possible hazards of such long-term therapy and weigh them against the benefits. In most instances the benefits obtained under proper supervision considerably outweigh any possible risks.