Ceruloplasmin Elevation and Synthesis in Rats with Transplantable Tumors
- 1 July 1979
- journal article
- research article
- Published by S. Karger AG in Enzyme
- Vol. 24 (2) , 85-95
- https://doi.org/10.1159/000458636
Abstract
In rats with transplantable mammary or hepatic tumors, plasma ceruloplasmin oxidase activity was increased 50-200%. This occurred progressively with tumors weighing 0.3% of body weight or more, and did not occur upon sham operation or implantation of normal tissue. Incorporation of [3H]-leucine indicated a specific enhancement of ceruloplasmin synthesis in the tumor-bearing rats, and a greater state of activation of the enzyme was observed. The mechanism of the increase in ceruloplasmin levels in rats and humans with cancer appears to involve increased synthesis and activation of the enzyme.This publication has 2 references indexed in Scilit:
- DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*Annals of the New York Academy of Sciences, 1964
- THE INCORPORATION OF COPPER INTO CERULOPLASMIN IN VIVO: STUDIES WITH COPPER64 AND COPPER67*Journal of Clinical Investigation, 1961