PLASMA LEVELS OF ETHYNYLOESTRADIOL AFTER ADMINISTRATION OF ETHYNYLOESTRADIOL OR MESTRANOL TO HUMAN SUBJECTS

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Abstract
The metabolism in human subjects of ethynyloestradiol (EE) or its 3-methylether (mestranol) labelled with 14C or 3H has been studied by numerous investigators (see Fotherby & James, 1972; Goldzieher & Kraemer, 1972). The rate of excretion of metabolites of the two compounds appears to be similar. Oestrogen methylethers are hydrolysed in vivo. After administration of the 3-methylethers of oestrone, oestradiol or oestriol to human subjects only small amounts of the ethers were detected in urine and excretion of the free oestrogens was slower by about 24 h than after administration of the free compounds (Brown, 1962). Williams (1969) identified EE in the urine of women receiving mestranol. However the rate of hydrolysis of mestranol and the blood level of EE attained, have not been studied. In the present investigation plasma levels of EE were measured in normal, healthy volunteers (3 male and 1 female). Plasma samples were obtained

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