A Gene Map of the Human Genome
- 25 October 1996
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 274 (5287) , 540-546
- https://doi.org/10.1126/science.274.5287.540
Abstract
The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/ .Keywords
This publication has 34 references indexed in Scilit:
- Genetic regulatory mechanisms in the synthesis of proteinsPublished by Elsevier ,2010
- The yeast genome — a common currencyNature Genetics, 1996
- DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1Science, 1996
- Gene–based sequence–tagged–sites (STSs) as the basis for a human gene mapNature Genetics, 1995
- Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's diseaseNature, 1995
- Predicting the total number of human genesNature Genetics, 1994
- Mining Treasures from 'Junk DNA'Science, 1994
- Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2ANature, 1993
- Genes and genomes: Chromosome bands – flavours to savourBioEssays, 1993
- The transcription map of mouse mitochondrial DNACell, 1978