Extremely Long Duration of Chronic Myeloid Leukaemia with Ph1 Negative and Ph1 Positive Bone Marrow Cells
- 1 May 1976
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Haematology
- Vol. 16 (5) , 321-325
- https://doi.org/10.1111/j.1600-0609.1976.tb00324.x
Abstract
A male patient still surviving 17 yr after the diagnosis of chronic myeloid leukemia (CML) is described. A chromosome analysis of the bone marrow 16 yr after the diagnosis revealed 84% Ph1 negative and 16% Ph1 positive cells, all containing the Y chromosome. The disease was very sensitive to treatment with busulfan but bone marrow hypoplasia was not induced. In some CML patients with such a double cell population, the prognosis may be extraordinarily good, and they run a considerable risk of being overtreated due to a pronounced sensitivity to alkylating drugs. Such rare cases should not serve as arguments for aggressive treatment of CML.Keywords
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