Tissue Distribution, Accumulation and Elimination of the Isomers of Benzene Hexachloride

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Abstract
The alpha, beta, gamma and delta isomers of benzene hexachloride (1,2,3,4,5,6-hexachlorocyclohexane) are preferentially stored in adipose tissue of rats and dogs. The degree of accumulation in adipose tissue of rats bears a direct relationship to the chronic toxicity of each isomer. The relative rates of accumulation in rat adipose tissue show that approx. maximal storage is accomplished within 6 wks. Upon removal of benzene hexachloride diet, alpha, gamma and delta isomers disappear from rat fat depots within 3 weeks; the beta persists in small amts. after 14 wks.