Water-Soluble Vitamin D in Human Milk: A Myth

Abstract
For the past 50 years, repeated analyses of human milk have shown an average of 20 IU/liter of vitamin D activity. Following the 1977 report of Lakdawala and Widdowson,1 which found that a large amount of water-soluble vitamin D sulfate was present in the whey (or water-soluble) fraction of human milk, the previous studies appeared to be in question. This study by Lakdawala and Widdowson reportedly confirmed earlier reports from Japan2-4 and France5 which not only demonstrated large quantities of vitamin D sulfate in human milk, but also strongly suggested that this vitamin D metabolite had biologic activity in rats.

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