Studies of parietal cell antibody in pernicious anemia.

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Abstract
Parietal cell antibody was detected by an immunofluorescent method in sera from 62 of 72 patients (86%) with adult pernicious anemia. The titer of parietal cell antibody in the serum was not related to the duration of the patient''s pernicious anemia and did not vary in individual patients over a period of up to 4 years. Parietal cell antibody was present in the gammaG-globulin fraction of serum; it was either absent or present in very low titers in the gammaA-globulin fraction, and it was not detected in the gammaM-globulin fraction. Parietal cell antibody was demonstrated in gastric juice from patients with pernicious anemia. It was present in the gammaG-globulin fraction, and its titer in the juice was considerably lower than that in the patient''s serum. Immunoglobulins were present in the mononuclear cells in the lamina propria of the gastric mucosa from patients with pernicious anemia. Parietal cell antibody could not be detected in mucosal extracts.