Elevated serum levels of IL-8 in patients with HIV infection
Open Access
- 1 August 1993
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Immunology
- Vol. 93 (2) , 149-151
- https://doi.org/10.1111/j.1365-2249.1993.tb07957.x
Abstract
SUMMARY: Scrum levels of IL-8 were determined in HIV-infected individuals and the results were compared with those for HIV controls. The IL-8 levels were measured by an ELISA with a MoAb and a polyclonal antibody to recombinant IL-8. The means and 95% confidence intervals of IL-8 in sera of 36 HIV-infected individuals and 32 matched controls were 275 and 216 349 pg/ml, and 8 and 4 14 pg/ml, respectively, showing a 34-fold increase in IL-8 in the circulation of HIV-infected individuals. This increase does not appear to be related to the disease state, infection or systemic medical agents. This finding suggests the possible involvement of IL-8 in the pathogenesis of HIV-induced disease.Keywords
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