Asbestos-Induced Epithelial Changes in Organ Cultures of Hamster Trachea: Inhibition by Retinyl Methyl Ether
- 18 January 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4428) , 311-313
- https://doi.org/10.1126/science.7350661
Abstract
The epithelium of the hamster trachea in organ culture undergoes hyperplasia and squamous metaplasia after exposure to the amphibole types of asbestos, crocidolite and amosite. These changes are inhibited when the synthetic vitamin A analog, retinyl methyl ether, is incorporated into the culture medium. These findings suggest a possible use for retinoids in the prevention and treatment of respiratory tract disease associated with environmental exposure to asbestos.Keywords
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