Electrophilic Amination and Azidation of Chiral α-Alkyl Phosphonamides: Asymmetric Syntheses of α-Amino α-Alkyl Phosphonic Acids†
- 1 January 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1994 (12) , 1272-1274
- https://doi.org/10.1055/s-1994-25679
Abstract
Stereoselective electrophilic aminations of chiral non racemic α-alkyl phosphonamides, derived from N,N′-dimethyl (R,R)-1,2-diamino-cyclohexane, proceed with moderate to excellent enantioselectivities. The products are hydrolyzed and reduced to the corresponding α-alkyl α-amino phosphonic acids. The sense of asymmetric induction was confirmed by X-ray crystal structure analysis.Keywords
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