BIOLOGIC BEHAVIOR AND TREATMENT OF INTRANSIT METASTASIS OF MELANOMA

  • 1 January 1980
    • journal article
    • research article
    • Vol. 150  (1) , 29-32
Abstract
The therapeutic approach to intransit metastasis of melanoma was surveyed in 52 patients with a clinical history of intransit lesions of melanoma. Ten patients were long term survivors. Two patients died at 23 and 28 mo., respectively, after surgical removal of the lesions, and at autopsy no evidence of recurrence was noted. All long-term survivors belong to the group of 35 patients that received intensive local management; all 17 patients given systemic chemotherapy or immunotherapy only died from progression of the disease. Every trial of systemic chemotherapy or systemic immunotherapy aiming to control these lesions of intransit metastasis failed. Systemic chemotherapy or systemic immunotherapy should not be used alone in the treatment of intransit metastasis. In addition to systemic treatment, the following regional modalities should be utilized persistently: hyperthermic perfusion, local immunotherapy, or excisions of wide strips of skin, subcutaneous fat and fascia around the lesions.

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