The antiviral activity of dideoxycytidine

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Abstract
2′,3′-Dideoxycytidine (ddc) is a 2′,3′-dideoxypyrimidine nucleotide which has been shown to be active against human immunodeficiency virus type 1 (HIV-1) in cell cultures. This article reviews some of the laboratory studies with this antiviral compound, and available pharmacokinctic and toxitity data from phase 1 studies of ddc alone and in alternation with zidovudine in patients with AIDS and ARC. Though ddc has potent activity against HIV-1 in vitro , serious toxic effects seen in phase 1 studies warrant continuation of trials to explore lower dosage regimens, alternation with zidovudine and intermittent therapy.

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