REFRACTORY DYSMYELOPOIETIC ANEMIA AND ACUTE-LEUKEMIA

  • 1 January 1984
    • journal article
    • research article
    • Vol. 63  (2) , 314-318
Abstract
Consecutive patients (117) with refractory dysmyelopoietic anemia (RDA) were followed and studied over 6 yr. All RDA cases had at least 2 marrow cell lines involved with dysplasia and usually all 3. Morphologically, the series could be divided into 55 cases that had primarily erythroid hyperplasia and 62 cases with primarily myeloid dysplasia. There was a significantly higher number of acute leukemias in the myeloid group, 21/63 (33.9%), than in the erythroid group, 7/55 (12.7%). Of the 117 cases, 64 had marrow culture studies performed using implanted diffusion chambers (DC) in an irradiated rat host. There was a highly statistically significant correlation between the development of leukemia and abnormal growth in DC during the RDA stage.