Inhibited Efficiency of Kidney Mitochondria Isolated from Rats Treated with Cyclosporin A
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 45 (1) , 43-45
- https://doi.org/10.1159/000184070
Abstract
The effect of cyclosporin A (CYA) on the respiration and phosphorylation in rat kidney mitochondria was studied. When CYA (50 mg/kg/day) was subcutaneously administered to rats for 4 days, the state 3 respiration and uncoupled respiration of succinate and glutamate/malate respiration was decreased. The respiratory control index was decreased in glutamate/male respiration. These ex vivo effects of mitochondrial dysfunction are discussed as CYA effects on kidney mitochondria occurring in the intact cell. The nephrotoxic effect of CYA could be demonstrated by increased excretions of urinary enzymes.This publication has 7 references indexed in Scilit:
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