Association of Autoantibodies with Anemia, Splenomegaly, and Glomerulonephritis in Experimental African Trypanosomiasis
- 1 February 1979
- journal article
- research article
- Published by JSTOR in Journal of Parasitology
- Vol. 65 (1) , 65-73
- https://doi.org/10.2307/3280204
Abstract
Rats experimentally infected with Trypanosoma brucei rhodesiense developed a syndrome characterized by anemia, splenomegaly and glomerulonephritis. Serologic evaluation revealed that the syndrome was accompanied by the presence of 3 autoantibodies-cold-active hemagglutinin, immunoconglutinin and antibody [Ab] to fibrinogen/fibrin products. Fluorescein isothiocyanate conjugated Ab tests showed the presence of fixed complement [C] and fibrinogen on trypanosomes and erythrocytes. All infected rats died by the 9th day of the infection with 5 animals showing signs of pulmonary involvement and shock. Autoantigens, autoantibodies and C probably caused this syndrome.This publication has 0 references indexed in Scilit: