Early ovarian ageing: a hypothesis: Detection and clinical relevance

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Abstract
An important scientific breakthrough of the 20th century, IVF helped open new horizons in medicine, such as pre‐implantation genetic diagnosis and embryonic stem‐cell therapy. A further contribution of assisted reproduction technology has been the better understanding of reproductive ageing. Data from IVF cycles suggest that there is a fixed time‐interval between accelerated decline of fertility and the menopause. This leads to the hypothesis that a significant proportion of asymptomatic women in the early thirties may be at risk of early onset of subfertility. IVF provides a model for the development of ovarian reserve tests, some of which appear promising as potential screening tools for early ovarian ageing in the general population.

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