Mortality and Fertility Response of Musca domestica Adults to Certain Known Mutagenic or Anti-Tumor Agents1

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Abstract
Experiments were conducted to evaluate several candidate antifertility substances for mortality and sterilant qualities using adults of Musca domestica L. Materials used were: methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), isopropyl methanesulfonate (IMS), tretamine, triphenyltin acetate (GC6936), triphenyltin chloride (GC8993), and hydroxyurea (HU). Flies were fed materials dissolved in the food media. Reproduction was evaluated based on the average larvae produced by each living female during each day of a 10-day test. Tretamine, MMS, EMS, and HU produced significant sterility at a dosage which did not affect mortality. GC6936 and GC 3993 also were effective chemosterilants, but toxicity at the sterilant threshold was excessive. IMS produced significant sterility from the control, but compared with the other treatments was an unsatisfactory sterilant.