A Statistical Confidence Interval for True Per Cent Reduction in Caries-Incidence Studies

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Abstract
A procedure based on the asymptotic theory was obtained for calculating the confidence interval and certain probabilities associated with true average percent reduction in caries incidence. Caries increments usually conform to non-normal law with unequal variances. This procedure applies when: the true average caries increment under control treatment is other than 0; the sample average caries increment under control treatment is other than 0; and the sample sizes are large. Theoretical and practical considerations in the use of this procedure were investigated. Numerical examples from 8 clinical studies are given.