Inhibition of S-adenosyl-L-homocysteine hydrolase by the aliphatic nucleoside analogue - 9-(S)-(2,3-dihydroxypropyl)adenine
- 1 January 1980
- journal article
- Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications
- Vol. 45 (11) , 3039-3044
- https://doi.org/10.1135/cccc19803039
Abstract
9-(S)-(2,3-Dihydroxypropyl)adenine, a nucleoside analogue with antiviral activity, inhibits the hydrolysis of S-adenosyl-L-homocysteine catalyzed by rat liver S-adenosyl-L-homocysteine hydrolase (Ki = 3.5 μM; Ki/Km = 5.6 . 10-2). The effect upon the synthesis of the substrate is much less pronounced.Keywords
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