Mutagenicity of Enantiomers of Penbutolol
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Drug and Chemical Toxicology
- Vol. 12 (1) , 77-83
- https://doi.org/10.3109/01480548908999145
Abstract
With a view to examine the effect of chirality and the cause of batch-to-batch variation in the mutagenicity of penbutolol, penbutolol enantiomers - isopenbutolol [R(+)-enantiomer] and penbutolol [S-)-enantiomer] - and two batches of Betapressin were tested employing the Ames Salmonella tester strain TA98. The mutagenic activity of R(+)-enantiomer was found to be similar to that of a batch of penbutolol with a high content of this optical isomer. The pharmaceutical form of penbutolol, Betapressin, exhibited either less or equal mutagenic effectiveness to the S(-)-enantiomer. In the presence of the S9 mix, the mutagenicity of R(+)-enantiomer was only slightly affected in the low dose range of 40 to 160 tig/plate. A metabolite of penbutolol, (RS) 1″-dehydropenbutolol, did not cause an increase in the number of revertants/plate.This publication has 3 references indexed in Scilit:
- DNA strand breaks and mutations caused by penbutolol, a beta blockerMutation Research/Genetic Toxicology, 1988
- Laboratory Studies on Cohesive Sediment Deposition and ErosionPublished by Springer Nature ,1988
- Revised methods for the Salmonella mutagenicity testMutation Research/Environmental Mutagenesis and Related Subjects, 1983