Plasma Mineralocorticoids, Plasma Renin, and Urinary Kallikrein in Salt-Sensitive and Salt-Resistant Rats

Publisher Website
Google Scholar
Abstract
Plasma aldosterone, deoxycorticosterone (DOC), 18-hydroxy-deoxycorticosterone (180H-DOC), and corticosterone were measured in Dahl salt-sensitive (S) and salt-resistant (R) rats. Plasma corticosterone and DOC were not different between strains but plasma aldosterone was decreased and plasma 180H-DOC increased in S compared to R. Plasma renin activity and urinary kallikrein excretion were both lower in S than R. Urinary kallikrein is known to vary directly with mineralocorticoid activity and 180H-DOC is a weak mineralocorticoid. The lower urinary kallikrein in the presence of elevated 180H-DOC could mean that urinary kallikrein differences between S and R are under independent genetic control from 180H-DOC.