Antibacterial Effects of Various Organic Substances upon the H37 Strain of Human Tubercle Bacilli in a Simple Synthetic Medium

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Abstract
The pronounced growth-inhibiting properties of Cm-, C12-, and C12-chain aliphatic bases are again emphasized. The simple compounds themselves, and the compounds joined to or combined with radicals or other molecules such as benzene derivatives, possess these properties. The simpler benzene derivatives tested had the same relatively weak growth-preventing power as the C6 and C7 straight-chain acids. One exception was catechol with OH groups in the 1,2 positions which inhibited at 10-2% cones. Sulfanil-amide had its low antibacterial power increased by substitution into its molecule of either the pyrimidine or the thiazole nucleus. Morpholine, a saturated ring with 1 NH group and 1 O atom had no antibacterial power. Rearrangements of certain molecules might result in increase of antibacterial powers: e.g., with Merthiolate, where substitution of some other element such as Cd or Mn for Hg might be advantageous; or, addition of a Ca or longer aliphatic chain to the Merthiolate molecule (modified or not, as before suggested) at the 4 position might be helpful. The possible applications for chemotherapeutic purposes are obvious since bacteriostatic powers, may be quite as important as bactericidal powers in such efforts.