Rapid high-performance liquid chromatographic method for the determination of propranolol in plasma
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 112 (4) , 407-409
- https://doi.org/10.1039/an9871200407
Abstract
An HPLC method has been developed that can determine propranolol and its chief metabolite, 4-hydroxypropranolol, in plasma without the necessity for a pre-injection clean-up step. Sample clean-up is achieved by using a pre-column in conjunction with a column-switching device so that proteinaceous and other contaminants by-pass the analytical column. Accurate determinations were possible in the range 20–1000 ng ml–1. A method is also described for improving the minimum detection level by the on-column concentration of analytes.Keywords
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