Pharmacological actions of ifenprodil in the rat isolated anococcygeus muscle

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Abstract
The effect of ifenprodil on the contractile responses of the rat anococcygeus muscle to noradrenaline, methoxamine, carbachol, potassium chloride and calcium chloride has been examined. Ifenprodil (10−8-10−7M) non-competitively antagonized noradrenaline and methoxamine-induced contractions while carbachol-induced responses were unaffected. Similarly, contractile responses to KCl (in tissues from reserpinized animals, or tissues bathed in Tyrode containing 10−6M phentolamine) and CaCl2 in tissues bathed with Ca2+-free depolarizing solution were blocked non-competitively by ifenprodil (10−7-10−6M). These findings suggest that ifenprodil possesses α-adrenoceptor antagonist activity, with intrinsic Ca2+ blocking properties.