Comparative biliary excretion of cephalosporins in normal and partially hepatectomized rats
Open Access
- 1 July 1982
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 22 (1) , 170-171
- https://doi.org/10.1128/aac.22.1.170
Abstract
The biliary excretion of six cephalosporins was examined in normal and partially hepatectomized rats. Cefamandole, cefazolin, cefuroxime, cefoxitin, and cephradine were excreted well in normal animals. In partially hepatectomized rats, the cumulative percentage of excretion reached only 11 to 36.8% of the control levels. Cephaloridine was excreted poorly in both groups.This publication has 1 reference indexed in Scilit:
- Biliary excretion of cephalosporins in rats: influence of molecular weightAntimicrobial Agents and Chemotherapy, 1980