Neuroleptic drugs attenuate calcium influx and tension development in rabbit thoracic aorta: effects of pimozide, penfluridol, chlorpromazine, and haloperidol.

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Abstract
This study was designed to determine whether neuroleptic drugs have Ca channel blocking activity in isolated rings of rabbit thoracic aorta. Previous findings that pimozide and penfluridol are Ca channel blockers were confirmed. The conclusion that these agents are selective for the voltage-sensitive Ca channel is not supported. Both haloperidol and chlorpromazine (which represent different classes of neuroleptic drugs) are also Ca channel blockers in vascular smooth muscle.