PRELIMINARY EXPERIENCE WITH ICI 35 868 AS AN I.V. INDUCTION AGENT: COMPARISON WITH ALTHESIN
Open Access
- 1 August 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52 (8) , 807-810
- https://doi.org/10.1093/bja/52.8.807
Abstract
In a small open dose-finding study the i.v. dose of ICI 35 868 required to induce anaesthesia in healthy adults was 2 mg kg−1. Comparison of this dose with Aithesin 0.05 ml kg−1 for i.v. induction, both injected over 30 s suggests that they have similar effects on heart rate, arterial pressure and breathing. The mean times to loss of eyelash re:flex were 57±SD 10.1 s (ICI 35868) and 46±SD 3.9s (Aithesin). The new drug was associated with pain and discomfort on injection in seven of 10 patients, but with less involuntary movement than occurred with Althesin.This publication has 2 references indexed in Scilit:
- PHARMACOKINETICS IN LABORATORY ANIMALS OF ICI 35 868, A NEW I.V. ANAESTHETIC AGENTBritish Journal of Anaesthesia, 1980
- ANIMAL STUDIES OF THE ANAESTHETIC ACTIVITY OF ICI 35 868British Journal of Anaesthesia, 1980