Human High-density Lipoprotein Associated Amyloid a Protein: Structural Characteristics, Relation to Apo A-I and A-II Concentrations, and Plasma Clearance Kinetics in the Rat
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Rheumatology
- Vol. 14 (2) , 201-208
- https://doi.org/10.3109/03009748509165505
Abstract
Five amyloid related low-molecular-weight apoproteins were isolated and characterized from the plasma high-density lipoprotein fraction of a patient with glomerulonephritis caused by basement membrane antibodies. Amino acid and carbohydrate analyses of apo SAA subfractions showed that they were non-glycosylated polypeptides rich in aspartic acid, glycine, glutamic acid, glutamine, and arginine. The apo SAA subtype pattern was similar to that described in some other pathological conditions. Following injections of the isolated SAA-rich high density lipoprotein fraction into rat circulation, similar disappearance curves were obtained for apo SAA and apo A-I.Keywords
This publication has 23 references indexed in Scilit:
- SERUM AMYLOID A PROTEINTransplantation, 1983
- Plasma clearance kinetics of the amyloid-related high density lipoprotein apoprotein, serum amyloid protein (apoSAA), in the mouse. Evidence for rapid apoSAA clearance.Journal of Clinical Investigation, 1983
- Nh2-terminal analysis of four of the polymorphic forms of human serum amyloid a proteinsBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982
- THE BIOLOGY OF SAA: IDENTIFICATION OF THE INDUCER, IN VITRO SYNTHESIS, AND HETEROGENEITY DEMONSTRATED WITH MONOCLONAL ANTIBODIES*Annals of the New York Academy of Sciences, 1982
- Partial amino acid sequence of three new apolipoproteins isolated from human high density lipoproteinsFEBS Letters, 1980
- Effect of moderate physical exercise on serum lipoproteins. A controlled clinical trial with special reference to serum high-density lipoproteins.Circulation, 1979
- Serum Amyloid AJournal of Clinical Investigation, 1978
- Some properties of antisera to serum amyloid A protein (SAA): inhibition of precipitation by complexing of SAA to albumin.The Journal of Experimental Medicine, 1976
- Connective tissue origin of the amyloid-related protein SAA.The Journal of Experimental Medicine, 1976
- Electrophoretic Heterogeneity of Polypeptide Chains of Specific AntibodiesScience, 1966