The Effect of Tryptophane Deficiency on the Jaws of Rats

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Abstract
Inhibition of both endochondral and periosteal bone formation was produced as a result of tryptophan deficiency. Regressive changes were observed at the end of 3 wks. in both the femur and in the alveolar process. Contrary to results on animals with dietary kidney damages produced by early choline deficiency, disturbed growth of bone and dental tissue following early tryptophan deficiency can be corrected by subsequent supplementation of the deficient diet. The pathologic changes were associated with a reduction of the amt. of osteoid tissue as well as osteoblastic activity. A striking feature of these expts. was the tremendous amt. of alveolar bone destruction which took place as a result of these deficiencies. Concomittant with the bone destruction there occurred fragmentation and disappearance of the attachment fibers.