Metabolism and Proliferation of Cultured Fibroblasts from Specimens of Human Palmar Fascia and Dupuytren'sContracture. The pathobiochemistry of connective tissue proliferation.

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Abstract
Cell cultures from 11 Dupuytren''s contracture and 6 normal palmar fascia specimens were established. The rates of sulfated glycosaminoglycan, collagen and DNA synthesis by means of incorporation of labeled precursors ([35S]sulfate, [3H]proline, [3H]thymidine) as well as the growth characteristics of the cell lines of both healthy and diseased were compared. The incorporation rates of [35S]sulfate and [3H]proline were significantly higher in Dupuytren than in healthy palmar fascia-deriving cell lines. In contrast, no differences in cell growth or DNA synthesis could be demonstrated. The abnormal capacity to synthesize sulfated glycosaminoglycans and collagen is attributed to a permanent modulation of cell characteristics when can be propagated into cell culture.

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