Hematotox1city of inhaled benzene to Sprague‐Dawley rats and AKR mice at 300 ppm
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Journal of Toxicology and Environmental Health
- Vol. 4 (4) , 605-618
- https://doi.org/10.1080/15287397809529683
Abstract
Sprague‐Dawley rats and AKR/J mice were exposed to 300 ppm benzene vapor for 6 h/d, 5 d/wk, for life. Rats exhibited lymphocytopenla, mild anemia, and moderately decreased survival. Mice showed severe lymphocytopenia and anemia accompanied by granulocytosis and reticulocytosis. Treated mice also showed significantly decreased survival and weight gain. No indications of a leukemlc or preleukemic response were observed in either species.This publication has 16 references indexed in Scilit:
- Types of Leukemia in Chronic Benzene Poisoning. A Study in Thirty-Four PatientsActa Haematologica, 1976
- Current Concepts of Chronic Benzene ToxicityCRC Critical Reviews in Toxicology, 1975
- Untersuchungen zur Leukopoese im Knochenmark der Ratte nach chronischer Benzol-InhalationAnnals of Hematology, 1970
- Long-term inhalation screening studies of benzene, toluene, o-xylene, and cumene on experimental animalsToxicology and Applied Pharmacology, 1970
- Chromosome studies on workers exposed to atmospheric benzene: The possible influence of agePublished by Elsevier ,1970
- STUDIES ON POISONING BY BENZENE AND ITS HOMOLOGUESIndustrial Health, 1969
- Toxicologic studies on hydrocarbonsToxicology and Applied Pharmacology, 1966
- Benzene Exposure and Aplastic Anemia Followed by Leukemia 15 Years LaterJAMA, 1963
- The hemopoietic tissue toxicity of benzene vaporsToxicology and Applied Pharmacology, 1963
- A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology, 1961