PHYSIOLOGY AND THERAPY OF CONVULSIVE DISORDERS
- 1 September 1947
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology & Psychiatry
- Vol. 58 (3) , 312-324
- https://doi.org/10.1001/archneurpsyc.1947.02300320063003
Abstract
THE EFFECTS of drugs on various properties of electroshock seizures in experimental animals have been described in previous communications from this laboratory.1 Many anticonvulsant drugs in nontoxic doses have been found to modify the seizure pattern, usually by shortening or abolishing the tonic phase. A simple and quantitative method of assay of anticonvulsant drugs has been developed on the basis of this selective action.1j Of the more widely used antiepileptic agents, diphenylhydantoin, phenobarbital and "tridione" (trimethadione) rank as named in decreasing order of effectiveness when examined by this method. It would seem important to determine whether the pattern of electroshock seizures in man can be modified by anticonvulsant drugs in doses known to be clinically effective in epilepsy. Such information might help to elucidate the mechanism of action of drugs in control of convulsive disorders. The common use of electroshock seizure therapy of certain psychiatric disorders provides anKeywords
This publication has 3 references indexed in Scilit:
- EFFECTS OF I(+)GLUTAMIC ACID AND OTHER AGENTS ON EXPERIMENTAL SEIZURESArchives of Neurology & Psychiatry, 1946
- PROPERTIES OF MAXIMAL SEIZURES, AND THEIR ALTERATION BY ANTICONVULSANT DRUGS AND OTHER AGENTSJournal of Neurophysiology, 1946
- THE EFFECT OF CELLULAR HYDRATION ON EXPERIMENTAL ELECTROSHOCK CONVULSIONSJournal of Neurophysiology, 1946