Evidence for Intracochlear Impedance Changes Following Ethacrynic Acid Administration
- 1 November 1979
- journal article
- Published by Wiley in Otolaryngology -- Head and Neck Surgery
- Vol. 87 (6) , 880-887
- https://doi.org/10.1177/019459987908700624
Abstract
The effects of intra-arterial 30-, 40-, and 50-mg/kg doses of ethacrynic acid upon cochlear function in guinea pigs were studied for periods of three to five hours. Cochlear potentials recorded in the first turn included the endocochlear potential, whole nerve response, cochlear microphonics, and summating potentials in scala media, scala tympani, and scala vestibuli. Evidence of organ of Corti damage at 50 mg/kg was found in addition to electrical impedance changes in the cochlear membranes at all dose levels.Keywords
Funding Information
- Deafness Research Foundation
This publication has 17 references indexed in Scilit:
- The ototoxic effects of ethacrynic acid in man and animalsThe Laryngoscope, 1976
- DYSFUNCTIONS OF ENERGY RELEASING AND CONSUMING PROCESSES OF THE COCHLEAThe Laryngoscope, 1973
- The Effects Of Ethacrynic Acid Upon The Cochlear Endolymph And Stria Vascularis:A Preliminary ReportActa Oto-Laryngologica, 1973
- Effects of intra-arterially and intravenously administered ethacrynic acid and furosemide on cochlear N1 in cats*1Toxicology and Applied Pharmacology, 1972
- Ototoxicity of the Ethacrynic AcidJAMA Otolaryngology–Head & Neck Surgery, 1972
- The effect of diuretics on cochlear potentials and inner ear fluids.The Laryngoscope, 1971
- Ototoxicity of New and Potent Diuretics: A Preliminary StudyJAMA Otolaryngology–Head & Neck Surgery, 1970
- Early changes in the cochlear duct from ethacrynic ACID: An electronmicroscopic evaluationThe Laryngoscope, 1970
- Ototoxicity of Ethacrynic Acid: Demonstrated in a Human Temporal BoneJAMA Otolaryngology–Head & Neck Surgery, 1969
- Studies on Ethacrynic Acid in Patients with Refractory EdemaAnnals of Internal Medicine, 1965