Ethionine administration in the rat. 2. Effects on the incorporation of [32P]orthophosphate and dl-[1-14C]leucine into the phosphatides and proteins of liver and plasma

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Abstract
The administration of ethionine (150-250 mg/animal) to either male or female rats for 24 to 72 hr. reduced the rate of incorporation of [P32]orthophosphate in vivo into the liver phosphatides by 40-50% and into the plasma phosphatides by 80-90%. The reduction in the rate of incorporation into the liver phosphatides was not restricted to the liver-lecithin fraction. Ethionine administration (150 mg/animal) for a shorter period (5 hr.) did not change the rate of incorporation of P32 orthophosphate into the liver phosphatides when rat-liver slices were incubated in serum in vitro; under the same conditions, the rate of incorporation of DL-1-C14 leucine into the liver and serum proteins and lipoproteins was reduced. The significance of these observations is discussed in relation to the action of ethionine in lowering the serum lipid and raising the liver triglyceride concentration in the intact animal.