The role of glycerylphosphorylcholine and glycerylphosphorylethanolamine in liver phospholipid metabolism

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Abstract
The specific radioactivities of the free glycerylphosphoryl-choline and glycerylphosphorylethanolamine in rat liver have been measured by isolating them chromatographically at various times after the injection of labeled phosphate. A comparison of their specific radioactivities with those of liver phosphatidyl-ethanolamine and phosphatidylcholine has suggested that they cannot act as major isotopic precursors of these phospholipids. Liver phosphatidylcholine obeys the correct radioactive criteria for being the precursor of glycerylphosphorylcholine, while similarly liver phosphatidylethanolamine fulfils the isotopic conditions necessary for being the precursor of glycerylphos-phorylethanolamine.