Application of the lod score method to detection of linkage between HLA and juvenile insulin‐dependent diabetes

Publisher Website
Google Scholar
Abstract
The lod score method was applied to 28 informative families with at least 1 child suffering from juvenile insulin-dependent diabetes (JIDD), assuming autosomal recessive inheritance, for detection of linkage between HLA and a susceptibility locus for this disease. These 28 families were pooled with 21 other families from the literature. The maximum lod scores were obtained for recombination fractions from 4-16%, according to the level of penetrance (10-90%). These high estimates of the recombination fraction are not in agreement with the hypothesis that the association between JIDD and specific HLA haplotypes is due to a simple linkage disequilibrium between the HLA region and a susceptibility locus for JIDD.