CHEMOTHERAPEUTIC STUDIES: PREPARATION OF SUBSTITUTED SULPHONAMIDES
- 1 January 1942
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Research
- Vol. 20b (1) , 5-13
- https://doi.org/10.1139/cjr42b-002
Abstract
A series of substituted sulphonamides has been prepared for a study of their chemotherapeutic activity against a number of different bacterial species. By condensing p-acetylaminobenzenesulphonyl chloride with primary aromatic and aliphatic amines, N4-acetyl-N1–substituted sulphanilamides were obtained. Hydrolysis with acid or alkali removed the acetyl group and gave the desired N1-substituted sulphanilamides.The appendix contains details of the techniques used in testing these sulphonamides. Although a few of the compounds described in this paper exhibit considerable in vitro activity, none of them possess, in vivo, chemotherapeutic properties equal to those of sulfapyridine or sulfathiazole.Keywords
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