The genetic toxicology of metal compounds: I. Induction of λ prophage in E coli WP2S(λ)
- 1 January 1984
- journal article
- research article
- Published by Wiley in Environmental Mutagenesis
- Vol. 6 (1) , 59-69
- https://doi.org/10.1002/em.2860060108
Abstract
A number of metal compounds have been shown to be human carcinogens. Others, while not proven human carcinogens, are able to cause tumors in laboratory animals. Short-term bacterial assays for genotoxic effects have not been successful in predicting the carcinogenicity of metal compounds. We report here the ability of some metal compounds to cause the induction of λ prophage in E coli WP2S(λ). By far the strongest inducing ability was observed with K2CrO4, followed by Pb(N03)2 > MnCl2 > Ni(OOCCH3)2 > CrCl2 > NaWO4 > Na2MoO4 > KMnO4. With the exception of chromate, long-term exposures in a narrow, subtoxic dose range were required in order to demonstrate phage induction. A new microtiter assay for λ prophage induction, which incorporates these features, is described. This system also was able to detect very small amounts of organic carcinogens.Keywords
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