Comparison of Some Enzyme Systems in Normal and Thyrotoxic Rat Livers

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Abstract
The activity of the following enzymes and enzyme systems have been shown to increase above the normal in the mitochondria from thyrotoxic rats' livers: over-all glutamate oxidation, succinoxidase, cytochrome oxidase, cytochrome c, and adenosine triphosphatase. During hypothyroidism the activity of these enzymes decreases. Mg++ ion concentration was not influenced by the thyroid hormone. The latent ATPase4 of thyrotoxic rat liver mitochondria is activated by shorter preaging periods at 37° than that of normal. In a whole homogenate of these same tissues the glucose-6-phosphatase activity, inorganic phosphate content and apparent protein level was also increased during thyrotoxicity.