CONNECTIVE TISSUE GROWTH IN ALGINIC ACID-GRANULOMA OF RATS

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Abstract
The growth of connective tissues in granuloma caused by subcutaneous injection of alginate proceeded very slowly, and reabsorption of collagen fibers scarcely took place. Relative amount of aminopoly-saccharides in collagen fibers was increased with granuloma growth and decreased with maturation and ageing. The administration of L-ascorbic acid (10 mg/100 g body weight) fairly accelerated the collagen fiber formation as determined by conversion of proline to hydroxyproline.