Altered Metabolism of Androgens in Elderly Men with Benign Prostatic Hyperplasia
- 1 October 1977
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 45 (4) , 695-701
- https://doi.org/10.1210/jcem-45-4-695
Abstract
Kinetics of testosterone, dihydrotestosterone (DHT) and 5α-androstane-3α,17β-diol (3α-diol) were studied in 7 elderly healthy men (ages 61 to 80 years) with benign prostatic hyperplasia (BPH). Clearance rates were determined by the constant infusion technique with labeled testosterone and DHT. Metabolic clearance rate (MCR), conversion ratio (CR), the transfer constants (ρ) and production rates (PB) were calculated. Plasma androgens were measured by specific radioimmuno-assays. Plasma testosterone was 516 ± 314 (sd) ng/dl, plasma DHT was 74.6 ± 19.6 (sd) ng/dl and plasma 3α-diol was 16.4 ± 4.1 (sd) ng/dl. An elevated DHT level in elderly men with BPH was confirmed. MCRT was 620 ± 65 (sd) liter/day and MCRDHT was 393 ± 50 (sd) liter/day. Both MCRT and MCRDHT in elderly men were significantly lower than in young men. PBT was 3.2 ± 2.1 (sd) mg/day and PBDHT was 291 ± 87 (sd) μg/day. PBDHT was the same in elderly and young men. DHT production is maintained in elderly men despite reduction of testosterone production. From the data, it was calculated that in contrast to young men where >80% of blood DHT is from secreted testosterone, over 50% in elderly men is derived from secretion or production of DHT by the testis or even more likely the prostate.Keywords
This publication has 4 references indexed in Scilit:
- Androgens in Patients with Benign Prostatic Hyperplasia Before and After ProstatectomyJournal of Clinical Endocrinology & Metabolism, 1976
- Measurement of Androstanediol in Plasma in a Radioimmunoassay using Celite Column ChromatographyFertility and Sterility, 1976
- COMPARISON OF ANDROGEN METABOLITES IN BENIGN PROSTATIC HYPERTROPHY (BPH) AND NORMAL PROSTATEJournal of Clinical Endocrinology & Metabolism, 1976
- The Formation of 5α-Androstane-3α,17β-diol by Dog ProstateEndocrinology, 1976