An Efficient and Selective Enzymatic Oxidation System for the Synthesis of Enantiomerically Pured-tert-Leucine
- 4 September 2003
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (20) , 3649-3650
- https://doi.org/10.1021/ol035314g
Abstract
[reaction: see text] d-tert-Leucine was prepared with an enantiomeric excess of >99% by an enzyme-catalyzed oxidative resolution of the racemic mixture of dl-tert-leucine with use of leucine dehydrogenase. The l-amino acid was oxidized completely due to coupling of the primary reaction with a highly efficient irreversible NAD(+)-regenerating step by NADH oxidase.Keywords
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